Preheat your oven to 375°F (190°C).
Prepare your pie crust in the 9-inch pie dish according to package instructions or roll out your homemade dough.
In a large mixing bowl, combine the shredded cheddar and Monterey Jack cheese, reserving a quarter for topping.
In another bowl, whisk together the eggs, half-and-half, and flour until smooth.
Gently fold in the chopped green chiles and salsa into the egg mixture.
Add the cheese mixture to the egg and chile mixture, stirring gently to combine, then pour into the prepared pie crust.
Bake the quiche for about 45-50 minutes, or until the center is set and the top is golden brown.
Let the quiche cool for about 10-15 minutes before slicing.