Wrap the 16 oz extra-firm tofu block in paper towels and place a heavy pan or similar weight on top; press for at least 15 minutes to remove excess moisture.
Unwrap the pressed tofu and cut it into about 1-inch bite-sized cubes; transfer the cubes to a large bowl.
In a small bowl, whisk together 2 tablespoons soy sauce, 2 tablespoons sesame oil, 1 tablespoon mirin, 1 teaspoon liquid smoke, 1 teaspoon garlic powder, 1 teaspoon brown sugar, and 1 teaspoon paprika (if using) until combined.
Pour the marinade over the tofu cubes and toss gently to coat all pieces; let the tofu marinate for about 15 minutes.
Preheat the air fryer to 375°F (190°C).
Arrange the marinated tofu cubes in a single layer in the air fryer basket, leaving small gaps for air circulation; you may need to cook in batches for best crisping.
Air-fry the tofu at 375°F for 10–15 minutes, shaking or turning the basket once or twice during cooking to ensure even browning, until edges are golden and crisp.
Remove the tofu from the air fryer and serve immediately, optionally garnished with sesame seeds and a dipping sauce if desired.
