Preheat your smoker to 225°F (107°C).
Prepare a foil 'boat' by placing a long sheet of heavy-duty foil on a large baking sheet and folding the sides up to form edges that will contain the salmon and any juices.
Pat the salmon dry with paper towels and place it skin-side down on the foil.
Brush the top of the fillet lightly with 1 to 2 tablespoons avocado oil to help the seasonings adhere.
Evenly sprinkle 2 teaspoons garlic powder, 2 teaspoons paprika, and 1 teaspoon sea salt over the salmon (adjust salt to taste). Add black pepper if desired.
Transfer the baking sheet with the foil-wrapped salmon to the preheated smoker. Close the lid and smoke for 30 to 60 minutes, checking the internal temperature after 30 minutes.
Remove the salmon when it reaches about 140–145°F (60–63°C). Note that the temperature will rise slightly while resting.
Let the salmon rest 10 to 15 minutes before slicing and serving with lemon wedges.