Preheat your oven to 350°F (175°C) to ensure it’s hot and ready for your casserole.
In a large skillet over medium heat, add the lean ground turkey and chopped onion. Cook until the turkey is browned and the onions are translucent, approximately 5-7 minutes.
Once the turkey is cooked, stir in the cumin, cayenne pepper, black pepper, and sea salt. Mix well to ensure that the spices are evenly distributed throughout the meat.
Pour in the salsa and stir to combine. Allow the mixture to simmer for about 2-3 minutes to meld the flavors together.
In a 9x13 inch baking dish, spread half of the tortilla pieces across the bottom. Layer half of the turkey and salsa mixture over the tortillas. Sprinkle half of the reduced-fat cheddar cheese on top. Repeat with the remaining tortillas, turkey mixture, and finish with the rest of the cheese.
Place the baking dish in the preheated oven and bake for 25-30 minutes, or until the cheese is bubbly and golden brown.
Once out of the oven, let the casserole cool slightly. Top it with diced avocado and diced tomato, if desired.