Mexican Style Lasagna
This Mexican Style Lasagna is a weeknight savior: layered, cheesy, and bright with cilantro. It swaps traditional noodles for whole-grain tortilla strips and uses lean ground turkey for a lighter protein that still delivers satisfying flavor. Tangy salsa, creamy cottage cheese, and melty mozzarella and cheddar come together to create a dish that feels indulgent but is simple to build. The recipe yields a cozy casserole perfect for family dinners or meal prep, and leftovers reheat beautifully for lunches later in the week.
Why this Mexican Style Lasagna works

Think of this as lasagna with a south-of-the-border twist. Tortilla strips create soft, absorbent layers that hold saucy turkey and cheese. Cumin and chili powder season the meat without overpowering the other components. Cottage cheese adds a creamy, slightly tangy middle layer that keeps the casserole moist while reducing the need for heavier ricotta. A final blanket of shredded cheddar and mozzarella melts into a golden, bubbly crown. Sprinkle fresh cilantro on top for a bright finish that keeps every bite lively.
Ingredients
- 1 pound lean ground turkey
- 12 ounces salsa jar, no sugar added
- 1 cup cottage cheese low-fat
- 1 cup mozzarella cheese part-skim
- 1 1/2 teaspoons cumin
- 1 1/2 teaspoons chili powder
- 1/4 teaspoon kosher or sea salt
- 1/4 teaspoon black pepper
- 1/4 cup cilantro fresh, plus more for garnishing
- 4 whole-grain tortillas cut into 2 inch strips (tortilla recipe)
- 1 cup cheddar cheese shredded, reduced-fat
Equipment
- Large skillet
- Mixing bowl
- 9×13-inch baking dish (or similar casserole dish)
- Wooden spoon or spatula
- Measuring spoons and cups
- Knife and cutting board
Prep notes

Preheat your oven to 375°F (190°C) so it’s ready once the layers are assembled. If your tortillas are fresh, cutting them into 2-inch strips is easiest with a sharp knife or kitchen shears. Chop the cilantro fine so it distributes evenly and measures cleanly into the layers. This recipe keeps ingredient amounts as listed; adjust only for personal dietary preferences after you’ve tested the original version.
Step-by-step directions

- Preheat the oven. Set the oven to 375°F (190°C) so it reaches temperature while you prepare the filling and assemble the lasagna.
- Cook the turkey. Heat a large skillet over medium heat. Add the 1 pound lean ground turkey and cook, breaking it up with a spoon, until it is no longer pink and any liquid has evaporated, about 6–8 minutes.
- Season the meat. Sprinkle 1 1/2 teaspoons cumin, 1 1/2 teaspoons chili powder, 1/4 teaspoon kosher or sea salt, and 1/4 teaspoon black pepper over the cooked turkey. Stir well to coat the meat evenly with the spices and cook for an additional 1 minute to toast the spices.
- Add the salsa. Pour the full 12 ounces of salsa (no sugar added) into the skillet with the seasoned turkey. Stir to combine and let the mixture simmer gently for 2–3 minutes so the flavors meld and the sauce heats through. Remove from heat.
- Mix the cottage cheese layer. In a medium bowl, combine 1 cup cottage cheese low-fat and 1/4 cup cilantro fresh (chopped). Stir until the cilantro is evenly distributed through the cottage cheese. This creates a creamy, herby layer for the lasagna.
- Prepare cheese for topping. In a separate bowl, mix 1 cup mozzarella cheese part-skim with 1 cup cheddar cheese shredded, reduced-fat. Set the combined cheeses aside; you’ll use them to finish the casserole.
- Assemble the first layer. Spray or lightly oil a 9×13-inch baking dish. Place a single layer of the 2-inch tortilla strips across the bottom to cover it—don’t worry about perfect overlap; you’re building multiple layers and slightly overlapped strips will soften and meld as the dish bakes.
- Add a meat layer. Spoon about one-third of the turkey and salsa mixture over the tortilla strips and spread it into an even layer with the back of the spoon.
- Add the cottage cheese layer. Dollop and gently spread roughly one-third of the cottage cheese and cilantro mixture over the meat. You don’t have to cover every square inch perfectly; the goal is even distribution so each bite has some creaminess.
- Repeat layers. Add another layer of tortilla strips, then another third of the turkey mixture, followed by another third of the cottage cheese mixture. Press down lightly so the layers settle and the tortillas absorb some sauce.
- Finish with tortillas and cheese. Lay the remaining tortilla strips across the top of the final cottage cheese layer. Spoon the remaining turkey mixture over those strips, spreading it to the edges. Sprinkle the combined mozzarella and cheddar cheeses evenly across the top layer.
- Bake until bubbly. Place the assembled dish in the preheated oven and bake for 20–25 minutes, or until the cheese is melted, bubbly, and lightly golden at the edges. If the top is browning too quickly, loosely tent the dish with foil for the remaining cooking time.
- Rest and garnish. Remove the lasagna from the oven and let it rest for 5–10 minutes before slicing. This short rest allows layers to settle and makes serving cleaner. Sprinkle additional chopped cilantro over the top for a bright, fresh finish.
- Serve. Cut the lasagna into squares and serve warm. Pair it with a simple green salad, sliced avocado, or a squeeze of lime if you like extra brightness.
Tips and variations
- To make the dish spicier, stir in a few dashes of hot sauce to the turkey mixture or use a spicier salsa.
- For extra veggies, fold in a cup of sautéed bell peppers or corn into the turkey-salsa mixture before layering.
- If you prefer a creamier middle, mix a beaten egg into the cottage cheese before spreading; this will set slightly during baking and create a richer texture.
- Leftovers keep well in an airtight container in the refrigerator for up to 4 days. Reheat in a 350°F oven until warmed through, or microwave portions for 1–2 minutes.
- To make the tortillas crispier, brush the strips lightly with oil and bake them on a sheet for 5 minutes before assembling. They will crisp but still soften once layered with sauce.
Make-ahead and storage
Assemble the lasagna in a baking dish, cover tightly with plastic wrap or foil, and refrigerate for up to 24 hours before baking. When ready to cook, remove the cover and bake from chilled, adding 5–10 extra minutes to the baking time until the cheese is bubbly and the center is hot. For longer storage, freeze the fully cooled lasagna (wrapped tightly) for up to 3 months. Thaw overnight in the refrigerator, then bake as directed.
Nutritional pointers
This version keeps things balanced with lean protein from ground turkey and reduced-fat cheeses. Using whole-grain tortillas increases fiber, and salsa adds flavor without added sugar. If you’re watching sodium, choose a low-sodium salsa and adjust the salt to taste.
Serving suggestions
Serve slices of Mexican Style Lasagna with complementary sides: a crisp green salad with lime vinaigrette, charred corn salad, or a simple cucumber and tomato salad tossed with lime and cilantro. Garnish each portion with a sprinkle of extra cilantro and an optional wedge of lime for brightness.
Final thoughts
Mexican Style Lasagna is a comforting hybrid that’s both easy to assemble and full of personality. It manages to feel indulgent while staying mindful of calories and convenience. Whether you’re feeding a hungry family or prepping dinners for the week, this layered casserole delivers big on flavor and texture without a complicated technique. Keep the ingredient ratios the same the first time through so you lock in the intended balance of sauce, filling, and cheese—then experiment with add-ins as you make it again.
Enjoy this crowd-pleasing casserole for a cozy dinner that reheats well and packs a satisfying punch of savory, cheesy goodness.

Mexican Style Lasagna
Ingredients
Equipment
Method
- Preheat the oven to 375°F (190°C).
- In a large skillet over medium heat, brown the ground turkey until no longer pink, breaking it up as it cooks.
- Drain any excess fat from the skillet, then stir in the salsa until the meat is evenly coated; remove from heat.
- In a mixing bowl, combine the cottage cheese, mozzarella, cumin, chili powder, salt, black pepper, and 1/4 cup chopped cilantro until blended.
- Spread half of the meat mixture in the bottom of a 9 x 13-inch casserole dish.
- Top with half of the cheese mixture, then arrange half of the tortilla strips over the cheese.
- Repeat the layers with the remaining meat, cheese mixture, and tortillas, then sprinkle the shredded cheddar evenly over the top.
- Cover loosely with foil and bake for 30 minutes, until heated through and cheese is melted. Remove the foil and bake 5 additional minutes to lightly brown the top.
- Let the casserole rest 5–10 minutes before serving, then garnish with additional cilantro if desired.
Notes
- Use no-sugar-added salsa to control sweetness.
- Drain excess fat after browning the turkey.
- Let the casserole rest so it sets for easier slicing.
